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Emerging from the protective environment of the uterus, the newborn is exposed to a myriad of microbes, and quickly establishes a complex microbiome that shapes the infant’s biology in ways that are only now beginning to come to light. Among these exposures are a number of potential pathogens. The host responses to these pathogens in the neonatal period are unique, reflecting a developing immune system even with delivery at term. Preterm infants are delivered at a time when host defense mechanisms are even less developed and therefore face additional risk. As such, the organisms that cause disease in this period are different from the pathogens that are common in other age groups, or the disease they cause manifests in more severe fashion. Developmental alterations in both innate and adaptive immune responses in neonates have been documented among many cell types and pathways over the last several decades. Contemporary insights into the human immune system and methodologies that allow an “omics” approach to these questions have continued to provide new information regarding the mechanisms that underlie the human neonate as an “immunocompromised host.” This Research Topic highlights studies related to this unique host-pathogen interface. Contributions include those related to the innate or adaptive immune system of neonates, their response to microbial colonization or infection, and/or the pathogenesis of microbes causing disease in neonates.
Infection --- Neonate --- Candida --- Sepsis --- Necrotizing enterocolitis --- Vaccine --- Immunity --- Microbiome
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Neuropathology --- Nervous system --- Newborn infants --- Diseases. --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Nervous Systems --- System, Nervous --- Systems, Nervous
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Infant, Newborn. --- Infant, Newborn, Diseases. --- Neonatal Diseases --- Disease, Neonatal --- Diseases, Neonatal --- Neonatal Disease --- Perinatology --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- infant --- newborn --- diseases --- Geriatrics --- gerontologie --- neonatologie
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Infant Care --- Infant, Newborn --- Neonatal Nursing --- Nursing Care --- methods --- Infants --- Newborn infants --- Pediatric nursing --- Pediatric nursing. --- Infant, Newborn. --- Care --- Care. --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Children --- Infants (Newborn) --- Baby care --- Infant care --- Newborns (Infants) --- Diseases --- Nursing --- Care and hygiene --- Neonatology --- Neonatal Nursing. --- Nursing, Neonatal --- Nursing, Perinatal --- Perinatal Nursing
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Pediatric neurology. --- Brain Diseases. --- Infant, Newborn. --- Nervous system --- Neurology --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Neonatology --- Brain Disorders --- CNS Disorders, Intracranial --- Central Nervous System Disorders, Intracranial --- Central Nervous System Intracranial Disorders --- Encephalon Diseases --- Encephalopathy --- Intracranial CNS Disorders --- Intracranial Central Nervous System Disorders --- Brain Disease --- Brain Disorder --- CNS Disorder, Intracranial --- Encephalon Disease --- Encephalopathies --- Intracranial CNS Disorder --- Diseases
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Critical congenital heart defects (CCHDs) are potentially life-threatening malformations that remain a significant cause of neonatal mortality and morbidity. Failure to diagnose these conditions shortly after birth may result in acute cardiovascular collapse and death. The identification of CCHDs by routine newborn clinical examination is routine in many countries, but consistently misses over a third of cases, and, although antenatal ultrasound screening can be very effective in early diagnosis, the provision and accuracy of ultrasound screening is highly variable. As most CCHDs present with mild cyanosis (hypoxaemia), which is frequently clinically undetectable, pulse oximetry is a rapid, simple, painless method of accurately identifying hypoxaemia, which has gained popularity as a screen for CCHD. This Special Issue of the International Journal of Neonatal Screening, devoted to ""Neonatal Screening for Critical Congenital Heart Defects (CCHDs)"", will consider the evidence for CCHD screening with pulse oximetry, the acceptability and cost-effectiveness of this intervention, the additional non-cardiac conditions which it may also identify, and international experiences of introducing CCHD screening across the globe.
n/a --- altitude --- CCHD screening in the US --- screening --- coarctation of aorta --- oxygen saturation --- neonates --- critical congenital heart disease screening --- newborn screening pulse oximetry --- home births --- health policy --- congenital heart disease --- neonatal screening --- pulse oximetry --- cost-effectiveness --- hypoxia --- neonate --- newborn --- critical congenital heart disease --- state screening --- pulse oximetry screening --- economic evaluation --- screening algorithm --- newborn screening --- Germany --- congenital heart defects
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Individualized Medicine --- Pediatrics --- Periodicals. --- Neonatology --- Personalized medicine --- Precision Medicine. --- Pediatrics. --- Neonatology. --- Child. --- Infant, Newborn. --- Personalized medicine. --- Individualized medicine --- Paediatrics --- Pediatric medicine --- Neonatal pediatrics --- Newborns --- Neonate --- Infants, Newborn --- Neonates --- Newborn --- Newborn Infant --- Newborn Infants --- Children --- Personalized Medicine --- Medicine, Individualized --- Medicine, Personalized --- Medicine, Precision --- medicine --- pediatrics --- neonatology --- metabolomics --- individualized medicine --- Medical care --- Pharmacogenetics --- Medicine --- Perinatology --- Newborn infants --- Minors --- Pharmacogenomic Variants --- Patient-Specific Modeling --- Diseases --- Health and hygiene --- P Health --- P-Health --- P-Healths --- Theranostics --- Predictive Medicine --- Medicine, Predictive --- Theranostic --- Precision medicine
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Surgical Procedures, Operative --- Child. --- Infant. --- Surgery, Operative --- Children --- Chirurgie opératoire --- Enfants --- Periodicals. --- Periodicals --- Surgery --- Périodiques --- Chirurgie --- Surgical Procedures, Operative. --- Surgery. --- neonate --- infants --- children --- oncology --- thoracic surgery --- neurosurgery --- Infants --- Minors --- Ghost Surgery --- Operative Procedures --- Operative Surgical Procedure --- Operative Surgical Procedures --- Procedure, Operative Surgical --- Procedures, Operative Surgical --- Surgery, Ghost --- Surgical Procedure, Operative --- Operative Procedure --- Procedure, Operative --- Procedures, Operative --- General Surgery --- Pediatric surgery --- Surgery, Pediatric --- Childhood --- Kids (Children) --- Pedology (Child study) --- Youngsters --- Age groups --- Families --- Life cycle, Human --- Diseases --- Treatment --- Surgical Procedures --- Procedure, Surgical --- Procedures, Surgical --- Surgical Procedure --- pediatric surgery --- pediatrics --- neonatology
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There is some talk about an antibiotic Armageddon, wherein untreatable post-operative infections and similarly untreatable complications after chemotherapy will occur. The now famous “O’Neill Report” suggests that, by 2050, more people could die from resistant bacterial infections than from cancer. We are still learning about all the subtle drivers of antibiotic resistance, realizing that we need a single “whole health” coordinated policy. We ingest what we sometimes feed to animals, yet there does not seem to be any new classes of antibiotics on the horizon. Maybe there is something that has been around forever that could could to our rescue: bacteriophages. Nevertheless, we have to do things differently. We must use antibiotics appropriately and for the correct indication, duration, and dosage with good practice and stewardship.. While by no means comprehensive, this book covers many topics regarding antibiotic stewardship. It also addresses older antibiotics, new combinations, and even new agents. Last but not least, this book features two excellent articles on bacteriophages. Refinements to animal models used in research for either human or animal benefit must be an ongoing aim for anyone working in this context, whether it be as an animal carrier, an animal user, a veterinarian, or an official. Unfortunately, the details of refinements are often overlooked in publications describing the research outcomes. This book includes manuscripts published in the Animals Special Issue “Refinements to Animal Models for Biomedical Research”. In this contemporary resource, we included 12 peer-reviewed papers that cover a range of approaches to the concept of refinement.
mouse --- blood sample --- well-being --- retrobulbar --- submandibular --- sublingual --- functional MRI --- rat anaesthesia --- refinement --- calves --- disbudding --- gene transcription --- cytokines --- pain --- meloxicam --- nCounter --- guinea pig --- Cavia porcellus --- captive bolt --- humane euthanasia --- laboratory animal --- humane killing --- piglet --- castration --- behaviour --- peri-operative --- vocalisation --- nociception --- neonate --- anaesthesia --- analgesia --- sheep --- survey --- preclinical research --- health --- nociceptive threshold --- horse --- cat --- dog --- camel --- 3R principles --- transdermal fentanyl patch --- grimace scores --- laboratory animals --- pain assessment --- rabbit --- postoperative analgesia --- facial expressions --- grimace scales --- mice --- rat --- animal research --- animal testing --- biomedical research --- history of science --- n/a
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Gestational diabetes mellitus (GDM) is one of the most common adverse medical conditions that occurs during pregnancy, and its prevalence is rising as part of a diabetes pandemic. Nutrition plays a key role in GDM, whether (1) as part of an ‘unhealthy’ diet, which contributes to its cause, or (2) as part of changes in dietary intake, which act as the frontline treatment for GDM (sometimes supplemented with exercise and pharmacological intervention). Dietary changes, therefore, can alter the risk of developing GDM in the first place, and once GDM has emerged during pregnancy, dietary changes can mitigate the risk of developing GDM-related complications, such as macrosomia, respiratory distress, hypoglycemia and jaundice in the neonate, pre eclampsia, increased need for caesarean section and placental abruption in the mother. In this Special Issue, we aim to highlight the role of nutrition in the aetiology of GDM, whether directly or indirectly through weight gain and obesity, and in its role as a GDM treatment to lower hyperglycemia and the risk of the aforementioned complications.
microbiome --- pregnancy --- obesity --- ketonuria --- Roseburia --- diet --- food frequency questionnaire --- glucose --- insulin secretion --- human milk --- breastfeeding --- gestational diabetes mellitus --- insulin-dependent diabetes mellitus --- preterm newborn --- gestational diabetes --- dietary patterns --- maternal nutrition --- dietary adaptations --- glycemic index --- postprandial glycemic response --- blood glucose prediction --- diabetes --- gestational weight gain --- macrosomia --- adiposity --- neonate --- exercise --- physical activity --- dietary carbohydrates --- diabetes-specific formula --- continuous glucose monitoring --- glycemic variability --- carbohydrate distribution --- mean amplitude of glucose --- breakfast diet --- platelet-activating factor --- tumor necrosis factor α --- methylglyoxal --- glycated albumin --- endocrine disruptors --- endocrine-disrupting chemicals --- bisphenol A --- BPA --- phthalates --- pregnancy outcomes --- eating speed --- cohort study --- prevention --- nutrition --- polyphenolic compounds --- bioactive compounds --- leptin resistance --- inflammation --- Mediterranean diet --- n/a
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